Research Statement
Our group develops and applies a variety of theoretical methodologies to study the thermodynamic, structural and dynamics of biointerphases with applications to biomaterials and drug delivery systems. Specific examples of systems that we study include: protein adsorption on polymer modified surfaces; lipid structure and phase behavior; model cell membranes; ligand-receptor binding. The molecular theoretical approaches that we develop enable the study of these complex interfaces in a large of time and length scales. Another general (and related) are of study in our group is the effect of spatial confinement on chemical equilibrium. For example, how acid-base equilibrium is modified when the reactants and products are in the vicinity of an interface.
Selected Publications
“Kinetics of Protein Adsorption and Desorption on Surfaces with Grafted Polymers”, Fang Fang, J. Satulovsky and I. Szleifer, Biophys. J. 89, 1516-1533 (2005).
“Ligand-receptor interactions in tethered polymer layers”, Gabriel Longo and I. Szleifer, Langmuir, 21, 11342-11351 (2005).
“Controlled Release of Proteins from Polymer Modified Surfaces”, Fang Fang and I. Szleifer, Proc. Nat. Acad. Sci. 103, 5769-5774 (2006).
“Phase diagram of a ternary mixture of cholesterol and saturated and unsaturated lipids calculated from a microscopic model”, R. Elliott, I. Szleifer, M. Schick, Phys. Rev. Lett. 96, 098101 (1-4), (2006).
“Phase behavior and charge regulation of weak polyelectrolyte grafted layers”, Peng Gong, Jan Genzer and I. Szleifer, Phys. Rev. Lett. 98, 018302(1-4) (2007).
“A Molecular Theory of Chemically Modified Electrodes by Redox Polyelectrolytes under Reversible Conditions: Comparison with Experiment, Mario Tagliazucchi, Ernesto J. Calvo, Igal Szleifer, J. Phys Chem. C, (in press).
Most Significant Awards
Raices-Cesar Milstein Fellowship (2007)
Fellow American Physical Society (2005)
American Chemical Society Akron Section Award (2005)
Camille Dreyfus Teacher-Scholar Award (1997)
NSF Career Award (1996)
Camille and Henry Dreyfus New Faculty Award (1991)
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