Research Statement
The Meade Lab research focuses on inorganic coordination chemistry for the study of molecular imaging of in vivo gene expression and intracellular messengers, transition metal enzyme inhibitors, and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research.
Selected Publications
Modo M, Beech JS, Meade TJ, Williams SC, Price J. A chronic 1 year assessment of MRI contrast agent-labelled neural stem cell transplants in stroke. Neuroimage, 2009, 47, T133-142.
Lin W, Hyeon T, Lanza G, Miqin MZ, Meade TJ. “Magnetic Nanoparticles for Early Detection of Cancer by Magnetic Resonance Imaging.” MRS Bulleti,n 2009, 34, 441-448.
Modo M, Meade TJ, Mitry RR. Liver cell labelling with MRI contrast agents. Methods Mol Biol, 2009 481:207-19. Review.
Meade TJ, Aime S. Chemistry of molecular imaging. Acc Chem Res., 2009 42(7):821.
Major JL, Meade TJ. Bioresponsive, cell-penetrating, and multimeric MR contrast agents. Acc Chem Res., 2009 42(7):893-903.
Harney AS, Lee J, Manus LM, Wang P, Ballweg DM, LaBonne C, Meade TJ. Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate. Proc Natl Acad Sci U S A, 2009 106(33):13667-72.
Bertin PA, Meade TJ. Novel redox active bifunctional crosslinkers from unsymmetrical 1,1'-disubstituted ferrocenes. Tetrahedron Letters. 2009, 50(38): 5409-5412.
Barker K, Eckermann AL, Sazinsky M, Hartings M, Abajian C, Georganopoulou D, Ratner M, Rosenzweig A, Meade TJ. Protein Binding and the Electronic Properties of Iron (II) Complexes: An Electrochemical and Optical Investigation of Outer Sphere Effects. Bioconjugate Chemistry, 2009, 20(10): 1930-1939.
Joshi, HM, Lin YP, Aslam M, Prasad PV, Schultz-Sikma, EA, Edelman R, Meade TJ, Dravid VP. Effects of Shape and Size of Cobalt Feritte Nanostructures on Their MRI Contrast and Thermal Activation. J. Phys. Chem., 2009, 113: 17761-17767.
Song Y, Xu X, MacRenaris KW, Zhang X, Mirkin CA, Meade TJ. Multimodal Gadolinium-Enriched DNA Gold Nanoparticle Conjugates for Cellular Imaging. Angew. Chem Int. Engl., 2009, 48(48), 9143-9147.
Hu F, MacRenaris KW, Waters EA, Liang T, Schultz-Sikma EA, Eckermann AE, Meade TJ. Ultrasmall, Water-Soluble Magnetite Nanoparticles with High Relaxivity for Magnetic Resonance Imaging. J. Phys. Chem., 2009, 113(49), 20855-20860.
Eckermann AL, Shaw J, Meade TJ. Kinetic Dispersion in Redox Active Dithiocarbamate Monolayers. Langmuir, 2009, in press.
Harney A, Meade TJ. Molecular imaging of in vivo gene expression. Future Medicinal Chemistry, 2009, in press.
Eckermann AL, Meade, TJ. Electrochemistry of Redox-Active Self Assembled Monolayers, Coord. Chem Rev., 2009, in press.
Trivedi ER, Harney AS, Olive MB, Podgorski I, Moin K, Sloane BF, Barrett AGM, Meade TJ, Hoffman BM. Tumor-Selective Optical Imaging With a Chiral Porphyrazine. PNAS, 2009, in press.
Hu F, MacRenaris K, Waters EA, Schultz-Sikma EA, Eckermann AL, Meade TJ. Highly Dispersible, Superparamagnetic Magnetite Nanoflowers for Magnetic Resonance Imaging. Chem. Comm., 2010, 46(1), 73-75.
Most Significant Awards
Illinois Biotechnology Industry Organization (iBIO) iCON Innovator Award (2009)
Miller Professor, University of California Berkeley (2009)
Northwestern University Excellence in Teaching Award (2008)
William Beaumont Award: Wayne County Medical Society (2007)
Allen & Constance Ford Distinguished Award, CaseWestern ReserveUniversity (2006)
Eileen Foell Chair in Cancer Research, Northwestern University, (2005)
Elected President – Society of Molecular Imaging - Membership>1,000 Chair (2005)
Committee- Imaging in 2020 IV, (2005)
FMC Award - Princeton University, (2004)
Elkin Distinguished Investigators Cancer Lecturer, Emory University (2003)
Neuroscience Award Lecture, Society for Neuro-Oncology (November 2002)
National Academy of Engineering Lecturer, Cleveland, Ohio, (2000)
Pendergast Lecturer, University of Pennsylvania (1999)
American College of Neuropharmacology Lecturer (1999)
Caltech Grubstakes Award (1996, 1998)
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