Research Statement
The Meade Lab research focuses on inorganic coordination chemistry for the study of molecular imaging of in vivo gene expression and intracellular messengers, transition metal enzyme inhibitors, and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research.
Selected Publications
Urbanczyk-Pearson, L.M, Meade, T.J., "Synthesis of a series of MRI Contrast Agents activated by ¾-Galactosidase." Nature Protocols, 2008, 3, 341-350.
Wang, P., Miller, J.E., Henling, L.M., Stern, C.H., Frank, N.L., Eckermann, A., Meade, T.J., "Synthesis and Characterization of Ruthenium and Rhenium Nucleosides." Inorg. Chem., 2007, 46,9853-9862.
Karfeild, L., Bull, S.R., Davis, N.E., Barron,A.E., Meade, T.J., "Use of a Genetically Engineered Protein for the Design of a Multivalent MRI Contrast Agent." Bioconjugate Chem. 2007, 18, 1697-1700.
Endres, P., Paunesku, T., Woloschak, G.E., Meade,T.J., "DNA-TiO2 Nanoconjugates Labeled with MR Contrast Agents." J. Am. Chem. Soc., 2007, 129, 15760-15761.
Urbanczyk-Pearson, L.M., Femia, F.J., Smith, J., Parigi, G., Eckermann, A.L., Duimstra, J.A., Luchinat, C., Meade, T.J., "Mechanistic Investigation of ¾-Galactosidase-Activated MR Contrast Agents." Inorg. Chem., 2008, 47, 56-68.
Frullano, Luca; Meade, T.J., "Multimodal MRI Contrast Agents." J. Biol. Inorg. Chem. 2007,12, 939-949.
Aslam, M.; Schultz, E.A., Sun,T., Meade, T.J., ;Dravid, P., "Synthesis of Amine-Stabilized Aqueous Colloidal Iron Oxide Nanoparticles." Crystal Growth & Design, 2007, 7, 471-475.
Major J.L., Parigi G., Luchinat, C., Meade T.J., "The synthesis and in vitro testing of a zinc-activated MRI contrast agent." Proc. Natl. Acad. Sci. USA, 2007, 104, 13881-13886.
Lee, J., Burdette, J. E., MacRenaris, K.W., Mustafi, D., Woodruff, T.K., Meade, T.J., "Rational Design, Synthesis, and Biological Evaluation of Progesterone-Modified MRI Contrast Agents." Chemistry & Biology 2007,14, 824-834.
Brekke, C.; Morgan, S. C.; Lowe, A. S.; Meade, T. J.; Price, J.; Williams, S. C. R.; Modo, M., The in vitro effects of a bimodal contrast agent on cellular functions and relaxometry NMR Biomed. 2007, 20, (2), 77-89.
Aslam, M.; Schultz, E. A.; Sun, T.; Meade, T.; Dravid, V. P., Synthesis of Amine-Stabilized Aqueous Colloidal Iron Oxide Nanoparticles Cryst. Growth Des. 2007, 7, (3), 471-475.
Frullano, L.; Tejerina, B.; Meade, T. J., Synthesis and Characterization of a Doxorubicin-Gd(III) Contrast Agent Conjugate: A New Approach toward Prodrug-Procontrast Complexes Inorg. Chem. 2006, 45, (21), 8489-8491.
Endres, P., J.; Macrenaris, K., W.; Vogt, S.; Allen, M., J.; Meade, T., J., Quantitative imaging of cell-permeable magnetic resonance contrast agents using x-ray fluorescence Mol. Imaging 2006, 5, (4), 485-97.
Duimstra, J. A.; Stern, C. L.; Meade, T. J., Magnetic and structural properties of a cyano-bridged 1D ruthenium(III)-nickel(II) coordination polymer Polyhedron 2006, 25, (14), 2705-2709.
Most Significant Awards
Eileen Foell Chair in Cancer Research, Northwestern University, (2005)
Elected President – Society of Molecular Imaging - Membership>1,000 Chair (2005)
Committee- Imaging in 2020 IV, (2005)
FMC Award - Princeton University, (2004)
Elkin Distinguished Investigators Cancer Lecturer, Emory University (2003)
Neuroscience Award Lecture, Society for Neuro-Oncology (November 2002)
National Academy of Engineering Lecturer, Cleveland, Ohio, (2000)
Pendergast Lecturer, University of Pennsylvania (1999)
American College of Neuropharmacology Lecturer (1999)
Caltech Grubstakes Award (1996, 1998)
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