Research Statement
Our research involves electron-nuclear double resonance study of metallo-enzymes, long-range electron transfer between proteins, and new macro-cycles for solid-state and biomedical applications.
Selected Publications
Tierney, D. L., Huang, H., Martasek, P., Masters, B. S., Silverman, R. B. & Hoffman, B. H. ENDOR Spectroscopic Evidence for the Position and Structure of NG-Hydroxy-L-Arginine Bound to Holo-Neuronal Nitric Oxide Synthase. Biochemistry 38, 3704-10 (1999).
Nie, H., Stern, C., Barrett, A. G. M. & Hoffman B. M. Decapitation of Dihydroporphyrazinediol Derivatives: Synthesis and X-Ray Structure of a Novel Seco-porphyrazine. Chem. Commun. 703-4 (1999).
Naito, N. R., Huang, H., Sturgess, V. V., Nocek, J. M. & Hoffman, B. M. Binding and Electron Transfer between Cytochrome b5 and the Hemoglobin a- and b-Subunits through the Use of [Zn, Fe] Hybrids. J. Am. Chem. Soc. 120, 11256-62 (1998).
Burdi, D., Willems, J. -P., Riggs-Gelasco, P., Atholine, W. E., Stubbe, J. A. & Hoffman, B. M. The Core Structure of X Generated in the Assembly of the Diiron Cluster of Ribonucleotide Reductase: 17O2 and H217O ENDCOR. J. Am. Chem. Soc.
Most Significant Awards
Member, National Academy of Sciences
NAS-NRC Fellow, Massachusetts Institute of Technology
Alfred P. Sloan Fellow
Career Development Award, National Institutes of Health
Fellow, American Association for the Advancement of Science
Chair, NIH-BMT Study Section
Chair, Bioinorganic Subdivision, American Chemical Society
Bruker Prize, Royal Society of Chemistry
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