Research Statement
We are investigating the relationship between structure and function in metalloproteins by using X-ray crystallographic, biophysical, and biochemical methods. Current projects in the laboratory are divided into two major areas, metal trafficking proteins and metalloenzymes.
Selected Publications
Lieberman, R. L & Rosenzweig, A. C. Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane, Nature 2005, 434, 177-182.
Lieberman, R. L., Kondapalli, K. C., Shrestha, D. B., Hakemian, A. S., Smith, S. M., Telser, J., Kuzelka, J., Gupta, R., Borovik, A. S., Lippard, S. J., Hoffman, B. M., Rosenzweig, A. C., & Stemmler, T. L. Characterization of the particulate methane monooxygenase metal centers in multiple redox states by X-ray absorption spectroscopy. Inorg. Chem. 2006, 45, 8372-8381.
Sazinsky, M. H., Mandal, A. L, Argüello, J. M., & Rosenzweig, A. C. Structure of the ATP binding domain from the Archaeglobus fulgidus Cu1+-ATPase. J. Biol. Chem. 2006, 281, 11161-11166.
Yatsunyk, L. A. & Rosenzweig, A. C. Copper binding and transfer by the N-terminus of the Wilson disease protein, J. Biol. Chem. 2007, 282, 8622-8631.
Most Significant Awards
David and Lucile Packard Fellow (1999)
Camille and Henry Dreyfus Teacher-Scholar Award (2001)
MacArthur Fellow (2003)
Honorary Degree, Doctor of Science, Amherst College (2005)
ACS Nobel Laureate Signature Award for Graduate Education in Chemistry (2006)
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