Research Statement
Chemistry and biology of transition metal receptors; transcriptional regulation mechanisms; metalloregulatory proteins; molecular and cell biology of copper, iron and zinc; biological chemistry of arsenic and molybdenum; metallochaperone proteins; mercury thiolate and protein chemistry; design of inorganic-based antitumor drugs and protease inhibitors; design of fluorescent zinc probes for use in biological systems.
Selected Publications
Chen, K., Yuldasheva, S., Penner-Hahn, J. E. & O'Halloran, T.V. An Atypical Linear Cu(I)-S2 Center Constitutes the High-Affinity Metal-Sensing Site in the CueR Metalloregulatory Protein. J. Amer. Chem. Soc. 2003, published online Sept. 10, 2003.
Changela, A., Chen, K., Xue, Y., Holschen, J., Outten, C. E., O'Halloran, T. V. & Mondragon, A. Molecular Basis of Selectivity and Sensitivity in Metal-Ion Recognition by CueR. Science 301, 1383-1387 (2003).
Finney, L.A. & O'Halloran, T.V. Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors. Science 300, 931-936 (2003).
Hitomi, Y., Outten, C. E., O'Halloran, T. V. Extreme Zinc-binding Thermodynamics of the Metal Sensor/Regulator protein, ZntR. J. Amer. Chem. Soc. 123 8614-8615 (2001).
Most Significant Awards
MERIT award, National Institutes of Health (2001-2010)
Fellow, American Association for the Advancement of Science (1999)
Guggenheim Fellow, John Simon Guggenheim Memorial Foundation (1998-1999)
Scientific Achievement Award, American Society for Biochemistry and Molecular Biology sponsored by Schering-Plough (1996)
The Camille and Henry Dreyfus Foundation Teacher-Scholar Award (1993-95)
Alfred P. Sloan Research Fellow (1991-1993)
Eli Lilly Biochemistry Grantee Award (1989-1991)
National Searle Scholars Award, The Chicago Community Trust (1987-90)
Presidential Young Investigator Award, National Science Foundation (1987-92)
Camille and Henry Dreyfus Foundation Distinguished New Faculty Award (1986)
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